Distinguishing Regulatory DNA From Neutral SitesPlease see The GALA database for the most current coordinates of the regulatory set.
Laura Elnitski, Ross C. Hardison, Jia Li, Shan Yang, Diana Kolbe,
Pallavi Eswara, Michael J. O'Connor, Scott Schwartz, Webb Miller, and Francesca Chiaromonte
Genome Res. 2003;13: 64-72
Regulatory Set 1
This set of known regulatory regions is limited to the smallest recognized segment containing full function.
Further information on past releasesClick here to see them as Human Genome Browser Custom Tracks displayed by chromosome.
This list of functional regions contains names and coordinates of an additional set of regulatory regions that have not been trimmed to show the smallest possible functional element with maximum activity. They range in size from 300-4000 bp. Updates will be posted when available.
Set 2 has not been trimmed.
This site contains a collection of experimentally determined regulatory regions found in human genes. It is divided into several collections based on the source of the information. These sequences represent the largest region prior to the trimming described above .Regulatory Sites from GenBank
A collection of 43 regulatory elements. Most of these sequences are defined in the literature as promoter elements with one or more recognized transcription factor binding sites. A few entries are from enhancers and intronic regulatory elements. supplied by Manolis Dermitzakis
Liver Specific Regulatory Sequences
A second data set contains sequences known to direct liver specific transcription.
supplied by William Krivan
Pairwise alignments with Annotation of Regulatory Elements
A third data set contains annotations for alignments between finished human and mouse sequences that were posted as part of the eight test regions selected by the homolgy group for analysis in August, 2001.
Human Globin gene promoters and regulatory elements
Annotations of the globin gene promoters are provided by Ross Hardison.
The CFTR promoter
Annotations of the regulatory elements in the CFTR promoter are based on the literature.
Muscle Specific Regulatory Regions
The collection of muscle specific regulatory elements defined inWasserman WW, Fickett JW.
Identification of regulatory regions which confer muscle-specific gene expression.
J Mol Biol. 1998 Apr 24;278(1):167-81.
please direct comments or questions to Laura Elnitski at email@example.com
Data made available by Laura Elnitski, Webb Miller, Ross Hardison, Scott Schwartz, Emmanouil Dermitzakis, Andrew Clark, William Krivan and Wyeth Wasserman