%define type %name LocusLink %color Blue %define type %name PubMed_general %color Red %define type %name NCBI %color Green %define type %name PubMed_regulatory %color Orange %define annotation %type LocusLink %range 162626 163980 %label HOXB1 %url http://www.ncbi.nlm.nih.gov/LocusLink/list.cgi?Q=HOXB1&ORG=&V=0 %define annotation %type PubMed_regulatory %range 160980 166276 %label HOXB1 regulators %summary A retinoic acid-triggered cascade of HOXB1 gene activation. Ogura T, Evans RM. Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):387-91. click to see Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7831296&dopt=Abstract %summary full text %url http://www.pnas.org/cgi/reprint/92/2/387 %summary Retinoic acid response elements as positive and negative regulators of the expression of the homeobox b-1 gene. De Luca LM, Ross SA. Nutr Rev. 1996 Feb;54(2 Pt 1):61-3. Review. %url http://www3.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=0&form=1&term=9053826 %define annotation %type PubMed_regulatory %range 162212 162537 %label HOXB1 r4 enhancer %summary corresponds to region mapped in mouse Hoxb1. Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. Popperl H, Bienz M, Studer M, Chan SK, Aparicio S, Brenner S, Mann RS, Krumlauf R. Cell. 1995 Jun 30;81(7):1031-42 click to see Abstract. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7600572&dopt=Abstract %define annotation %type PubMed_regulatory %range 160846 162537 %label r4_enh_r3/r5_repressor %summary Role of a Conserved Retinoic Acid Response Element in Rhombomere Restri ction of Hoxb-1. Michele Studer, Heike Popperl, Heather Marshall, Atsushi Kuroiw a, Robb Krumlauf. Science, New Series, Vol. 265, No. 5179. (Sep. 16, 1994), pp. 1728-1732. click to see Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&lis t_uids=7916164&dopt=Abstract %define annotation %type LocusLink %range 148469 150311 %label HOXB2 %url http://www.ncbi.nlm.nih.gov/LocusLink/list.cgi?Q=HOXB2&ORG=&V=0 %define annotation %type LocusLink %range 147345 147352 %label BOX1 %summary Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site. Vesque C, Maconochie M, Nonchev S, Ariza-McNaughton L, Kuroiwa A, Charnay P, Krumlauf R. EMBO J. 1996 Oct 1;15(19):5383-96. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8895582&dopt=Abstract %define annotation %type PubMed_regulatory %range 147372 147380 %label KROX20_site %summary The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation. Nonchev S, Maconochie M, Vesque C, Aparicio S, Ariza-McNaughton L, Manzanares M, Maruthainar K, Kuroiwa A, Brenner S, Charnay P, Krumlauf R. Proc Natl Acad Sc U S A. 1996 Sep 3;93(18):9339-45. click to see Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8790331&dopt=Abstract %summary full text %url http://www.pnas.org/cgi/reprint/93/18/9339 %define annotation %type PubMed_regulatory %range 146372 146843 %label HOXB2 r3/r5 enhancer %summary Corresponds to region of mouse Hoxb2 promoter. The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation. Sham MH, Vesque C, Nonchev S, Marshall H, Frain M, Gupta RD, Whiting J, Wilkinson D, Charnay P, Krumlauf R. Cell. 1993 Jan 29;72(2):183-96. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8093858&dopt=Abstract %define annotation %type NCBI %range 146372 146843 %label HOXB2 r3/r5 enhancer %summary HOXB2 r3/r5 enhancer %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=Nucleotide&list_uids=264663&dopt=GenBank %define annotation %type PubMed_regulatory %range 146892 147073 %label r4_enhancer %summary Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Maconochie MK, Nonchev S, Studer M, Chan SK, Popperl H, Sham MH, Mann RS, Krumlauf R. Genes Dev. 1997 Jul 15;11(14):1885-95. click to see Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9242495&dopt=Abstract %define annotation %type PubMed_regulatory %range 147476 148327 %label enhancer %summary Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cel ls. Vieille-Grosjean I, Huber P. J Biol Chem. 1995 Mar 3;270(9):4544-50. Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=78762 23&dopt=Abstract %summary full text %url http://www.jbc.org/cgi/content/full/270/9/4544 %define annotation %type PubMed_regulatory %range 146969 146983 %label enhancer %summary Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Jacobs Y, Schnabel CA, Cleary ML. Mol Cell Biol. 1999 Jul;19(7):5134-42. Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10373 562&dopt=Abstract %summary full text %url http://mcb.asm.org/cgi/content/full/19/7/5134?view=full&pmid=10373562 %define annotation %type PubMed_regulatory %range 146372 150311 %label HOXB2 %summary Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins. Ferretti E, Marshall H, Popperl H, Maconochie M, Krumlauf R, Blasi F. Development. 2000 Jan;127(1):155-66. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10654609&dopt=Abstract %define annotation %type LocusLink %range 140904 143044 %label HOXB3 %url http://www.ncbi.nlm.nih.gov/LocusLink/list.cgi?Q=HOXB3&ORG=&V=0 %define annotation %type PubMed_regulatory %range 136198 136344 %label r5_regulator %summary Segmental regulation of Hoxb-3 by kreisler. Manzanares M, Cordes S, Kwan CT, Sham MH, Barsh GS, Krumlauf R. Nature. 1997 May 8;387(6629):191-5. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9144291&dopt=Abstract %define annotation %type NCBI %range 119417 137849 %label HOXB3_5'_end %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=Nucleotide&list_uids=4504466&dopt=GenBank %define annotation %type PubMed_general %range 119417 137849 %label HOXB3_5'_end %summary Description of alternate transcripts and P2 promoter. The human HOX gene family. Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E. Nucleic Acids Res. 1989 Dec 25;17(24):10385-402. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2574852&dopt=Abstract %define annotation %type PubMed_regulatory %range 140904 143044 %label HOXB3 %summary Segmental regulation of Hoxb-3 by kreisler. Manzanares M, Cordes S, Kwan CT, Sham MH, Barsh GS, Krumlauf R. Nature. 1997 May 8;387(6629):191-5. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9144291&dopt=Abstract %summary Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes. Manzanares M, Cordes S, Ariza-McNaughton L, Sadl V, Maruthainar K, Barsh G, Krumlauf R. Development. 1999 Feb;126(4):759-69. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9895323&dopt=Abstract %summary full text %url http://www.biologists.com/Development/126/04/dev1355.html %define annotation %type PubMed_regulatory %range 119417 119532 %label HOXB3_P2 %summary Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions. Sham MH, Hunt P, Nonchev S, Papalopulu N, Graham A, Boncinelli E, Krumlauf R. EMBO J. 1992 May;11(5):1825-36. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?CMD=Text&DB=PubMed %define annotation %type LocusLink %range 115050 116646 %label HOXB4 %url http://www.ncbi.nlm.nih.gov/LocusLink/list.cgi?Q=HOXB4&ORG=&V=0 %define annotation %type PubMed_regulatory %range 120403 120419 %label DR5 element %summary corresponds to mouse DR5 element. Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway. Gould A, Itasaki N, Krumlauf R. Neuron. 1998 Jul;21(1):39-51. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9697850&dopt=Abstract %define annotation %type PubMed_regulatory %range 114897 114995 %label minimal promoter %summary Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2. Giannola DM, Shlomchik WD, Jegathesan M, Liebowitz D, Abrams CS, Kadesch T, Dancis A, Emerson SG. J Exp Med. 2000 Nov 20;192(10):1479-90. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11085749&dopt=Abstract %define annotation %type NCBI %range 119235 119341 %label HOXB4 CB2 enhancer %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=Nucleotide&list_uids=1911528&dopt=GenBank %define annotation %type PubMed_regulatory %range 118834 119466 %label enhancer site A %summary Multiple spatially specific enhancers are required to reconstruct the p attern of Hox-2.6 gene expression. Whiting J, Marshall H, Cook M, Krumlauf R, Rigby PW, Stott D, Allemann RK. Genes Dev. 1991 Nov;5(11):2048-59. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&lis t_uids=1682218&dopt=Abstract %define annotation %type PubMed_regulatory %range 115617 115709 %label Mus_Fugu homology %summary Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes. Aparicio S, Morrison A, Gould A, Gilthorpe J, Chaudhuri C, Rigby P, Krumlauf R, Brenner S. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1684-8. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7878040&dopt=Abstract %summary full text %url http://www.pnas.org/cgi/reprint/92/5/1684 %define annotation %type PubMed_regulatory %range 115086 116510 %label enhancer site C %summary Multiple spatially specific enhancers are required to reconstruct the p attern of Hox-2.6 gene expression. Whiting J, Marshall H, Cook M, Krumlauf R, Rigby PW, Stott D, Allemann RK. Genes Dev. 1991 Nov;5(11):2048-59. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&lis t_uids=1682218&dopt=Abstract %define annotation %type PubMed_regulatory %range 116510 117878 %label enhancer site B %summary Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Whiting J, Marshall H, Cook M, Krumlauf R, Rigby PW, Stott D, Allemann RK. Genes Dev. 1991 Nov;5(11):2048-59. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1682218&dopt=Abstract %define annotation %type PubMed_regulatory %range 119235 119341 %label Mus_Fugu_homology %summary CR3 region, Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes. Aparicio S, Morrison A, Gould A, Gilthorpe J, Chaudhuri C, Rigby P, Krumlauf R, Brenner S. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1684-8. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7878040&dopt=Abstract %summary full text %url http://www.pnas.org/cgi/reprint/92/5/1684 %summary Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns. Gould A, Morrison A, Sproat G, White RA, Krumlauf R. Genes Dev. 1997 Apr 1;11(7):900-13. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9106661&dopt=Abstract %define annotation %type PubMed_regulatory %range 119235 119341 %label HOXB4 CB2 enhancer %summary HOXB4 CB2 enhancer. Comparative analysis of chicken Hoxb-4 regulation in transgenic mice. Morrison A, Chaudhuri C, Ariza-McNaughton L, Muchamore I, Kuroiwa A, Krumlauf R. Mech Dev. 1995 Sep;53(1):47-59. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8555111&dopt=Abstract %define annotation %type NCBI %range 113856 115052 %label HOXB4 promoter seq. %summary corresponds to the mapped HoxB4 promoter region. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=Nucleotide&list_uids=437874&dopt=GenBank %define annotation %type PubMed_regulatory %range 115630 115698 %label HOXB4 HB1 element %summary contains conserved homeodomain binding sites in HoxB4. Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila. Haerry TE, Gehring WJ. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13884-9. Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8943030&dopt=Abstract %summary full text %url http://www.pnas.org/cgi/content/full/93/24/13884 %summary A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs. Keegan LP, Haerry TE, Crotty DA, Packer AI, Wolgemuth DJ, Gehring WJ. Mech Dev. 1997 May;63(2):145-57. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9203138&dopt=Abstract %summary A conserved cluster of homeodomain binding sites in the mouse Hoxa-4 intron functions in Drosophila embryos as an enhancer that is directly regulated by Ultrabithorax. Haerry TE, Gehring WJ. Dev Biol. 1997 Jun 1;186(1):1-15. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9188748&dopt=Abstract %summary full text %url http://www.idealibrary.com/links/citation/0012-1606/186/1 %define annotation %type PubMed_regulatory %range 113856 115052 %label HOXB4 %summary corresponds to mapped HoxB4 promoter Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Whiting J, Marshall H, Cook M, Krumlauf R, Rigby PW, Stott D, Allemann RK. Genes Dev. 1991 Nov;5(11):2048-59. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1682218&dopt=Abstract %summary Multiple positive and negative regulatory elements in the promoter of the mouse homeobox gene Hoxb-4. Gutman A, Gilthorpe J, Rigby PW. Mol Cell Biol. 1994 Dec;14(12):8143-54. Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7969151&dopt=Abstract %define annotation %type PubMed_regulatory %range 114881 115043 %label Mus HOXB4 regulation %summary Multiple positive and negative regulatory elements in the promoter of the mouse homeobox gene Hoxb-4. Gutman A, Gilthorpe J, Rigby PW. Mol Cell Biol. 1994 Dec;14(12):8143-54. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7969151&dopt=Abstract %define annotation %type PubMed_regulatory %range 110644 114446 %label enhancer D %summary corresponds to HoxB enhancer D. Selectivity, sharing and competitive interactions in the regulation of Hoxb genes. Sharpe J, Nonchev S, Gould A, Whiting J, Krumlauf R. EMBO J. 1998 Mar 16;17(6):1788-98. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9501100&dopt=Abstract %summary full text %url http://www.emboj.org/cgi/content/full/17/6/1788 %define annotation %type PubMed_regulatory %range 106068 109233 %label enhancer E %summary corresponds to HoxB enhancer E. Selectivity, sharing and competitive interactions in the regulation of Hoxb genes. Sharpe J, Nonchev S, Gould A, Whiting J, Krumlauf R. EMBO J. 1998 Mar 16;17(6):1788-98. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&lis t_uids=9501100&dopt=Abstract %summary full text %url http://www.emboj.org/cgi/content/full/17/6/1788 %define annotation %type LocusLink %range 99686 101159 %label HOXB5 %url http://www.ncbi.nlm.nih.gov/LocusLink/list.cgi?Q=HOXB5&ORG=&V=0 %define annotation %type PubMed_regulatory %range 99686 101159 %label HOXB5 %summary Growth factors and dexamethasone regulate Hoxb5 protein in cultured murine fetal lungs. Chinoy MR, Volpe MV, Cilley RE, Zgleszewski SE, Vosatka RJ, Martin A, Nielsen HC, Krummel TM. Am J Physiol. 1998 Apr;274(4 Pt 1):L610-20. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9575880&dopt=Abstract %define annotation %type LocusLink %range 95216 96953 %label HOXB6 %url http://www.ncbi.nlm.nih.gov/LocusLink/list.cgi?Q=HOXB6&ORG=&V=0 %define annotation %type NCBI %range 92404 94410 %label HOXB6 enhancer %summary HOXB6 LMP-like enhancer %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=Nucleotide&list_uids=755452&dopt=GenBank %define annotation %type PubMed_regulatory %range 92404 94410 %label HOXB6 LMP-like enhancer %summary DNA sequence polymorphism within hominoid species exceeds the number of phylogenetically informative characters for a HOX2 locus. Ruano G, Rogers J, Ferguson-Smith AC, Kidd KK. Mol Biol Evol. 1992 Jul;9(4):575-86. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1352841&dopt=Abstract %summary Analysis of LacZ reporter genes in transgenic embryos suggests the presence of several cis-acting regulatory elements in the murine Hoxb-6 gene. Eid R, Koseki H, Schughart K. Dev Dyn. 1993 Mar;196(3):205-16. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8104549&dopt=Abstract %define annotation %type NCBI %range 92404 94410 %label HOXB6 enhancer %summary corresponds to HoxB6 enhancer %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=Nucleotide&list_uids=1836045&dopt=GenBank %define annotation %type PubMed_regulatory %range 92696 92934 %label LPM_enhancer %summary corresponds to HoxB6 enhancer. Conserved regulatory element involved in the early onset of Hoxb6 gene expression. Becker D, Jiang Z, Knodler P, Deinard AS, Eid R, Kidd KK, Shashikant CS, Ruddle FH, Schughart K. Dev Dyn. 1996 Jan;205(1):73-81. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8770553&dopt=Abstract %define annotation %type LocusLink %range 82445 85523 %label HOXB7 %url http://www.ncbi.nlm.nih.gov/LocusLink/list.cgi?Q=HOXB7&ORG=&V=0 %define annotation %type PubMed_regulatory %range 81024 82364 %label HOXB7 promoter %summary corresponds to mouse B7 promoter. Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice. Kress C, Vogels R, De Graaff W, Bonnerot C, Meijlink F, Nicolas JF, Deschamps J. Development. 1990 Aug;109(4):775-86. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1977573&dopt=Abstract %define annotation %type PubMed_regulatory %range 86956 103008 %label antisense transcripts %summary antisense transcripts mapped from TIGR EST clusters THC524170, THC524171, THC524169, THC506892 %url http://www.tigr.org/tdb/hgi/searching/reports.html %define annotation %type PubMed_regulatory %range 82150 82564 %label HOXB7 promoter %summary corresponds to mouse B7 promoter. Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice. Vogels R, Charite J, de Graaff W, Deschamps J. Development. 1993 May;118(1):71-82. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8104144&dopt=Abstract %summary full text %url http://www.biologists.com/Development/118/01/dev7158.html %define annotation %type PubMed_regulatory %range 82150 82356 %label HOXB7 promoter %summary corresponds to mouse B7 promoter (footprinted regions are mapped in dark blue). Characterization of the murine Hox-2.3 promoter: involvement of the transcription factor USF (MLTF). Zwartkruis F, Hoeijmakers T, Deschamps J, Meijlink F. Mech Dev. 1991 Mar;33(3):179-90. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1677811&dopt=Abstract %define annotation %type PubMed_regulatory %range 80673 81013 %label HOXB7 enhancer %summary Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice. Vogels R, Charite J, de Graaff W, Deschamps J. Development. 1993 May;118(1):71-82. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8104144&dopt=Abstract %summary full text %url http://www.biologists.com/Development/118/01/dev7158.html %define annotation %type PubMed_regulatory %range 81024 82524 %label intergenic enahncer %summary Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice. Kress C, Vogels R, De Graaff W, Bonnerot C, Meijlink F, Nicolas JF, Deschamps J. Development. 1990 Aug;109(4):775-86. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1977573&dopt=Abstract %define annotation %type LocusLink %range 78647 80161 %label HOXB8 %url http://www.ncbi.nlm.nih.gov/LocusLink/list.cgi?Q=HOXB8&ORG=&V=0 %define annotation %type PubMed_regulatory %range 77596 78454 %label B8 promoter %summary The murine Hox-2.4 promoter contains a functional octamer motif. Zwartkruis F, Hoeijmakers T, Deschamps J, Meijlink F. Nucleic Acids Res. 1992 Apr 11;20(7):1599-606. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1349742&dopt=Abstract %define annotation %type NCBI %range 73338 74133 %label HOXB8 regulator %summary corresponds to mouse upstream cis-regulatory sequence %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=Nucleotide&list_uids=4165862&dopt=GenBank %define annotation %type PubMed_regulatory %range 73338 74133 %label HOXB8 regulator %summary Regulation of the Hoxb-8 gene: synergism between multimerized cis-acting elements increases responsiveness to positional information. Charite J, de Graaff W, Vogels R, Meijlink F, Deschamps J. Dev Biol. 1995 Oct;171(2):294-305. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed &list_uids=7556914&dopt=Abstract %define annotation %type PubMed_regulatory %range 73338 74133 %label HOXB8 CDX sites %summary 4 CDX sites in the HOXB8 regulatory region that are similar to the mouse Hoxb8 sites Transducing positional information to the Hox genes: critical interaction of cdx gene products with position-sensitive regulatory elements. Charite J, de Graaff W, Consten D, Reijnen MJ, Korving J, Deschamps J. Development. 1998 Nov;125(22):4349-58. Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9778495&dopt=Abstract %summary full text %url http://www.biologists.com/Development/125/22/dev2329.html %define annotation %type LocusLink %range 67093 70462 %label HOXB9 %url http://www.ncbi.nlm.nih.gov/LocusLink/list.cgi?Q=HOXB9&ORG=&V=0 %define annotation %type PubMed_regulatory %range 66594 66875 %label promoter %summary Corresponds to promoter of mouse HoxB9. The regulation of the murine Hox-2.5 gene expression during cell differentiation. Kondo T, Takahashi N, Muramatsu M. Nucleic Acids Res. 1992 Nov 11;20(21):5729-35. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1360646&dopt=Abstract %define annotation %type PubMed_regulatory %range 137934 137950 %label RXR site %summary matches mouse RARE in RAIDR5. Langston AW, Thompson JR, Gudas LJ. Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis. J Biol Chem. 1997 Jan 24;272(4):2167-75 Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8999919&dopt=Abstract %summary full text %url http://www.jbc.org/cgi/content/full/272/4/2167 %define annotation %type PubMed_regulatory %range 82445 85523 %label HOXB7 %summary Srebrow A, Friedmann Y, Ravanpay A, Daniel CW, Bissell MJ. Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells. J Cell Biochem. 1998 Jun 15;69(4):377-91. Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9620166&dopt=Abstract %summary full text %url http://www3.interscience.wiley.com/cgi-bin/abstract/35593/START %define annotation %type PubMed_regulatory %range 110782 110798 %label RARE %summary Close match to RARE Packer AI, Crotty DA, Elwell VA, Wolgemuth DJ. Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element. Development. 1998 Jun;125(11):1991-8. Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9570764&dopt=Abstract %summary full text %url http://www.biologists.com/Development/125/11/dev4970.html %define annotation %type PubMed_regulatory %range 136568 13658 %label RARE %summary Close match to RARE Packer AI, Crotty DA, Elwell VA, Wolgemuth DJ. Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element. Development. 1998 Jun;125(11):1991-8. Abstract %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui ds=9570764&dopt=Abstract %summary full text %url http://www.biologists.com/Development/125/11/dev4970.html %define annotation %type PubMed_regulatory %range 166281 166294 %label 3'DR2 %summary A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Marshall H, Studer M, Popperl H, Aparicio S, Kuroiwa A, Brenner S, Krumlauf R. Nature. 1994 Aug 18;370(6490):567-71. %url http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7914354&dopt=Abstract